Traverso

Traverso is a complete solution from recording to CD Mastering. By supplying many common tools in one package, you don't have to learn how to use lots of applications with different user interfaces. This considerably lowers the learning curve, letting you get your audio processing work done faster!

Is a GPL licensed, cross platform multitrack audio recording and editing suite, with an innovative and easy to master User Interface. It's suited for both the professional and home user, who needs a robust and solid DAW

Homepage - http://traverso-daw.org
More info - http://traverso-daw.org/documentation.html
Review - http://www.softpedia.com/reviews/linux/Traverso-Review-48701.shtml

Sorry don't know enough about registry to say how much it interacts.