start-up error message

Don't know if this has been covered in another post, but I did a search and couldn't find the exact error message I'm getting. When I start up Gaim and a couple of the other portable apps I've downloaded, I'm getting the following error message:

There is no disk in the drive. Please insert a disk into drive \Device\Harddisk3\DR6

I hit continue and the application comes up fine. Is there something I can change in the settings somewhere to eliminate the error message?

Thanks.