GnuCash Problem & Crash

GnuCash has taken to opening displaying the following error:
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GnuCash could not obtain the lock for V:\GnuCashPortable\Data\Profile\FILENAME

That database may be in use by another user, in which case you should not open the database. What would you like to do?

Open Anyway Create New File Quit
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There is no other user accessing it. I select Open Anyway. Within a few minutes I get an error message that gnucash-bin.exe has crashed.

I've encountered this on two different XP SP2 pro machines.

Log file follows:

* WARN [guid_init()] only got 2986 bytes.
The identifiers might not be very random.
* WARN Could not spawn perl: Failed to execute child process (No such file or directory)
* WARN gdkselection-win32.c:1068: OpenClipboard failed: Invalid window handle.

Any insights anyone?

Thanks,

--Allen