phython develope ?

I can't really understand what your saying but...

1. As far as I know you can develop a Portable Application in any language
2. If you want to create an application with Python the interpreter itself has to be portable. Nevertheless, if you choose to compile your python script into an executable your program must not use the registry and the program's configuration files must be able to be redirected to a different path.
3. Anything else you want to know can be found here