I know everyone here has a plethora of apps that were made portable, but there are loads of programs that weren't designed to be run off a flash drive that can and do. It'd be nice to get a list of such programs going, i know of a few, but definitly not all of them.
The one that I can't live without:
Bloodshed Dev C++ 5.0b - C++ IDE
http://www.bloodshed.net/devcpp.html
when i'm away from my Borland IDE, dev c++ definitly comes in handy 
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Notepad++
http://notepad-plus.sourceforge.net
Vintage!
The Adware/Spyware checker "Ad-Aware SE" runs quite well from a flash drive.
http://www.lavasoft.com/products/ad-aware_se_personal.php
Tim
Geek w/o portfolio
Things have got to get better, they can't get worse, or can they?
Hmm...hopefully these haven't been mentioned before. All are freeware except KeyPass
Minesweeper X - Minesweeper clone
POP Peeper - Web mail/pop checker
allSnap - Windows snapper.
DM2 - Window manager (on top, roll-up, min. to tray etc.)
MouseImp - Let's you grab and scroll windows with your mouse.
SlickRun - Um...best command type utility ever...probably been mentioned many times.
Console - Nice windows console replacement
KeyPass - *SHAREWARE* password manager. Far better than keepass.
Mp3tag - The best audio file tagger.
Rainlendar - Free calendar/organizer.
Moffsoft FreeCalc - Nice calculator program.
I don't know if anyone's posted how to run slickrun in "portable mode". this is straight from the author's post:
"There's actually a feature in SlickRun designed for running SlickRun from a thumbdrive.
Put all of the files on the keychain. Also grab the rtl60.bpl,vcl60.bpl,and vclx60.bpl files from your Windows system folder, and put them on the keychain. You may want to copy your MagicWords and Jot.Txt files from C:\documents and settings\yourprofile\application data\slickRun and put them in the same folder as well.
Place a new textfile in the same folder as sr.exe; name the file slickrun.local.
Now, SlickRun from the keychain. "
plucked from here:
http://groups.msn.com/bayden/slickrun.msnw?action=get_message&mview=0&ID...