I have a usb disk which can integrate an ISO file into it just like the SanDisk U3 System do, I would like to see PortableApps support launching apps in such a way, for example the launcher on the read-only CD-ROM part and all other data stored on the R/W data part.
We have no plans to support such an arrangement. Drives of this type are mostly gone these days. Drive with a read/write switch are similarly gone and optical drives are going away, so we no longer test or support read-only installs.
Sometimes, the impossible can become possible, if you're awesome!