Interoperability of portable apps, is possible?

Well, is this possible? I mean, is possible that installed apps to be "aware" of other intalled apps, instead of using the Operating System defaults? (Like, PortableThunderbird being aware that PortableFirefox is installed and open the links from a mail there)

I've searched through the forum, and only found this old thread https://portableapps.com/node/700 about that topic, but, since it's from early 2006, and I can't find anything related since then.

And, in case that isn't possible, there is some workaround (portable, of course) to achieve this?

Thanks in advance.