I have Google Chrome portable 37.0.2062.120 which I alternate between two machines.
As of yesterday, each time I move my PA stick between machines and start Google Chrome, it deletes my profile. If I look in settings I see a message to the effect that another programme corrupted my profile and it has been reset to default.
Copying my profile from backup restores normal operation. Closing and re-opening Chrome on the same machine causes no problem - only swapping between machines.
I've also noticed that a new Google extension is being installed (without even asking me). It's something to do with search but I didn't pay much attention before deleting it. This is probably not related to the problem but I thought I'd mention it just in case.