UPDATE: Skype Portable has been released!
Over on the Request Apps Forum, a question quickly led to a discussion about crafting a Portable version of Skype. Being careful to not modify things to the point of violating the user agreement, why don't we try to iron out a solution on this forum?
Now, here are a few relevant posts to start from:
So, does anybody have a surefire method to make Sykpe portable?