Okay, i just bought new 16gb sandisk cruzer flash drive.
Before it i used Transcend Jetflash 512mb.
After i copied all data, including portableapps, on cruzer, i got one small problem.
Firefox was extremely slow. (Standart Firefox portable, non-u3)
I disabled about ten addons, but i still get lags and freezes when i try to move on page or open new. Lags about 1-5 secs.
On transcend firefox working perfectly. But CheckFlash said that cruzer have read/write speed about x3 times faster than jetflash.
Pegtop PStart also working slower on cruzer, but other apps seems to work much faster...
What i can do about that problem?
P.S. Sorry for my bad english 
P.P.S oh i forgot. Firefox pipelines tweak performed. From addons...
Firebug, Yslow, Greader watcher, Gmail notifier, stylish, greasemonkey, livejournal tools, pixel perfect, ie tab, multiproxy switch, update notofier, twitterfor, adblock plus, download helper, useragent switcher, lastpass, firecookie, delicious official
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I have the same drive (SanDisk Cruzer Micro 16GB) and I can tell you from experience that it's sluggish. Its read speeds are actually phenomenal (Windows reports ~18MB per sec whenever I back it up), but it's lucky to get 3MB/sec write on a good day. Trying to run FFP on it is an exercise in patience, which is one of the reasons I switched to Chrome (the other being that I just really like Chrome. :D).
Interestingly, when I tested it earlier, it's faster than my JD FireFly for copying small files, but large files choke it. I originally thought it was the reverse... But this makes sense, because I'm pretty sure the Cruzer drives are specifically optimized for ReadyBoost, which requires fast incremental writes.