I noticed the same problem as derousse described in the following topic
https://portableapps.com/node/15810#comment-100512
In the same topic Simeon gave this advise:
it should get moved from the /Data to the App/keepass folder wneh you start the App and back after you close it.
Maybe something got wrong and it now uses the KeePass.ini in the App/keepass folder. If you move it manually to the /Data/settings folder, it should be working the way its supposed to.
This works but there are two issues we should think of.
1. This problem shouldn't happen at all. Is there some error in portable version in regard to this feature?
2. How to backup ini file in this situation? We have to check in both places. That's strange and inconvenient.
3. Is it possible to show the location of the ini file with settings to KeePass so that portableapps platform wouldn't have to move it back and forth?
If the third option is possible that would be the best solution.