I am in favor of a portable scandisk to run a scan on a drive, be it hard drive, or the usb flash drive itself. This would be very helpful, as my inlaws comp wont run a scan disk or defrag, but with the portable defrag program, it defragged! Also I am in favor of a malware, adware, and spyware removal app. This would help alot as I know alot of people whose computers are infected and don't even know it until a scan is ran.
ClamWin Antivirus Portable. It's already been done. Welcome to PortableApps.com.
Quamquam omniam nescio, nec nihil scio.
In addition to ClamWin Antivirus Portable and JkDefrag Portable, you can also grab the current PortableApps.com Platform 2.0 Beta 3 test release in the Beta forum. In the options menu there is an option to Check Disk for Errors that automatically runs a scandisk right from the PortableApps.com Menu.
Sometimes, the impossible can become possible, if you're awesome!