I've installed portable apps on my hard drives for years without a problem (Firefox, VLC, many more). However, I notice VLC takes FOREVER to open compared to the "regular" (non-portable) version. This leads me to a question that people ask but I can never answer:
Are portable apps "on your PC" generally slower? If so, why? Has anyone ever tested?
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The antivirus programs tend to slow down the portable versions due to the way they are compressed. Try turning off the AV and see they load quicker. I have addde an exception to my AV not to scan my PortableApps directory because of the slowness.