It would be very nice if there would be portable version of X-Chat 2, lightweight and easy to use IRC chat application.
It's open-source, but official Windows build is shareware - but that's not a problem,
there are free unofficial Windows builds, which have exactly same features (except graphical smileys :D) - http://www.silverex.org/news/
It also doesn't uses registry, so I believe it would be easy to make portable version of it.