Hello,
I have set Portable Google Chrome as my system default browser. This works great for clicking links in other non-browser applications, however the issue I am seeing is: Chrome comes up from an external click in a new window without any extensions, settings, or browser history from the normal portable setup.
I believe what is happening is Windows sends the URLs to the main chrome.exe instead of GoogleChromePortable.exe and so it doesn't look in the portable location for my user profile & settings.