I'd like to see a portable version of Hot Potatoes, a software that I like using for school.
The Hot Potatoes suite includes six applications, enabling you to create interactive multiple-choice, short-answer, jumbled-sentence, crossword, matching/ordering and gap-fill exercises for the World Wide Web. Hot Potatoes is freeware, and you may use it for any purpose or project you like. It is not open-source.
Although there is a zip file available that can be run from a USB drive, the software creates several registry keys and file associations.
There is also a Java version but I haven't tested it and it is slightly outdated.