weird chrome portable issue

So I can get chrome portable on my sandisk thumb drive no worries. But if I remove the drive and reinsert it, it will loose connection and go straight to the classic all snap page. Now if I change the drive letter of the USB drive, I immediately get connectivity the next time I boot the usb drive. If I use a drive letter that i previously used for the usb drive at some point before I get the issue back again. Does anyone have any idea of what is going on? I am using the latest version of chrome portable.