The only thing that helps when I delete the Data directory and recreate my settings. Annoying, but just a little. Is there a cure for that?
Also, sometimes I want to run two notepad files (now from one install, not two - https://portableapps.com/node/38265) and it says one instance is already running, I can't run another. But I have found no consistency when I can run two instances and when I cannot.