I got this stupid problem. I when I run my portable gaim from the portable apps menu, I get this error message:
App\gtk not found. Please check your configuration.
When I launch game from a launch bat file containing:
... then I also get the same error.
When I browse into \PortableApps\GaimPortable and call GaimPortable.exe directly, then it works fine.
I changed the SettingsDirectory in GaimPortable.ini to my .gaim settings dir. Other than that, it's a clean install. It can't be this because then it wouldn't work when I double-clicked on PortableApps\GaimPortable\GaimPortable.exe.