Program: BOINC
License: Open Source
Description: Allows users to donate their CPUs to grid computing (for SCIENCE!).
Website: http://boinc.berkeley.edu/
There is an old, outdated, abandoned version still available (https://portableapps.com/node/17295), but an update to this program is desperately needed. There would be a solid market for additional testers and users located at www.worldcommunitygrid.org - they recently updated their SSL certificate, and the PortableBOINC no longer works with their project.
*fingers crossed*