How can I run multiple instances of the same program simultaneously on more than machine (using cloud installation)

When attempting to use the apps in that fashion, you're trying to make two different running copies of the same app compete for the same set of data/settings. This isn't what portable apps are designed for. They are designed to be run one place at a time, closed, then run somewhere else.

You simply can't do that because you would be attempting to run exactly the same application in multiple locations, passing user settings backward and forwards between the stored application and the independent systems in use at the same time. Not even fully network aware software can do that when it's fully installed, unless all user files are stored and accessed from different user file locations.

Think it through more thoroughly and liken what you are suggesting to how a normal computer network operates, with essential file locking in place to prevent individual users from editing files already in use by another user, It's would be a recipe for irreconcilable file conflicts when user data files are moved between the base application and the users' PC, edited differently on those 'remote' PCs, and then copied back to the same base application in a different sequence as the remote applications are shut down.