Chrome suddenly not working

I've had Chrome on this USB stick for a while. I used to use it, without a hint of issue, at my old job, on a W7 machine. At my new job, I have W10 and, at the beginning, it worked fine. Then over the past couple weeks it's gone from having to click it a couple times to open to this morning, where the cursor will "work" for about 15 seconds, then stop and act as if nothing happened and Chrome hasn't opened. Other portable apps open fine.