Kaspersky Total Security 17.0.0: "Обнаружена вредоносная программа; PDM:Worm.Win32.BSS.ScreenLock (...) \app\skype\phone\skype.exe". skype.exe is deleted, and "Skype Portable | PortableApps.com": "Skype Portable cannot be started, You may wish to re-install to fix this issue, (ERROR: Skype.exe could not be found)".
Your antivirus is currently experiencing a false positive on Skype itself. That file is directly from Microsoft and downloaded on install. Either that or your copy got infected after it was installed. The actual Skype.exe from Microsoft downloaded by sPortable 184.108.40.206 is clean under both MetaDefender and VirusTotal and has an MD5 of 62422f283fd6f3df4486114a145b5a3a.
Sometimes, the impossible can become possible, if you're awesome!