Conflict of access with firefox dektop when a portable version already launched

I use a portable Firefox version ESR 52.2.0, and I already configured this version in mono instance. when I try to access a web page with the Firefox desktop version, a tab on the poratable version is displayed.
is there any solution that disable the display of a firefox Desktop tab on the firefox portable version knowing that I want to keep the configuration in mono instance of the portable version that I use?