Using the PortableApps FirefoxPortable/SeaMonkeyPortable profile folders with non-portable Firefox/SeaMonkey

Hello,

(1)
Is it possible to use non-portable Firefox/SeaMonkey with a PortableApps Firefox/SeaMonkey profiles by using the "-profile" command-line option?

So, for example, suppose we have our non-portable Firefox/SeaMonkey installed in the following locations respectively:

C:\Applications\firefox-52.9.1
C:\Applications\seamonkey-2.49.5

And also, suppose we have PortableApps Firefox/SeaMonkey installed in the following locations respectively:

C:\PortableApps\FirefoxPortableLegacy52
C:\PortableApps\SeaMonkeyPortable

Then, our question is, can we run:

"C:\Applications\firefox-52.9.1\firefox\firefox.exe" -profile "C:\PortableApps\FirefoxPortableLegacy52\Data\profile"

"C:\Applications\seamonkey-2.49.5\seamonkey\seamonkey.exe" -profile "C:\PortableApps\SeaMonkeyPortable\Data\profile"

Will this work seamlessly, or did PortableApps in any way modify the directory structure/contents of the the Firefox/SeaMonkey profile folders (so that this might not work)?

(2)
Our next question is: When run as a non-portable application (as described above), does Firefox/SeaMonkey write to any other folder besides the profile folder - if so, where?

Thanks!