Paint.NET has been updated and according to its author no longer needs .NET installed. See https://forums.getpaint.net/topic/118660-paintnet-43-is-now-available/, "no more .NET to install!". It also now has portable zips for download, but not in PortableApps format.
Given these updates, is it possible to create a PortableApps installer for Paint.NET?
Many thanks