I have a 1 TB USB Drive which I use reasonably regularly.
My PC is a Win 10 HP computer 64 bit, a few years old.
Now when Portable Apps opens it minimises after saying "file access denied".
At the same time it does call and install updates.
Can anyone please help??
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Bugs must be reproducible..
When the issue is related to a computer (or its related OS), it won't be easy to re-simulate the same bug.
Try making basic tests, like using another drive/computer, etc.
“My brain is only a receiver, in the Universe there is a core from which we obtain knowledge, strength and inspiration. I have not penetrated into the secrets of this core, but I know that it exists.”
― Nikola Tesla ―
What filesystem is the drive formatted to?
If it is NTFS there may of been an update that sets access permissions on NTFS drives.
Or your Anti-Virus may be interfering (false positive or otherwise)
More details will help others to be able to help you.