Thunderbird Portable to Thunderbird migration?

I have been happily using Thunderbird portable for some long time now (I see my membership here is 17+ yrs). In past years I did use it to travel with just a USB drive or a hard drive, but in more recent times, I am realizing I am now only ever on my PC, or on my own laptop, just plugging my drive into which ever I will be using at the time (PC at home and laptop to travel)

I was thinking with only these two computers, maybe I could revert to two installations of the standard Thunderbird and simplify my life by no longer shuttling the drive back and forth. My current email accounts are all IMAP: Gmail, Google workspace, and Protonmail accounts.

Part of me feels there is an advantage to keeping a single install (my current portable version of Thunderbird), where with two installations, if one wasn't used for for a month or more, it would have some updating needed when being opened up after a break. My single Portable version on the other hand is used multiple times each day, and is always current.

Another thought is that with my current set-up, in a true emergency, I can just grab my tiny hard drive on the way out the door and have everything with me no matter the situation.

It is a long time since I have had multiple installations of an email program, so what other considerations or advantages/downsides should I consider in thinking about making this change?