If you are looking at e-learning eXe is a nice little e-learning content generator which works rather well as a portable app. It is relatively new but is maturing very well and usuable without having any knowledge of the underlying API or XML manifests.
It will export in a few formats (SCORM 1.2, IMS content package, HTML, plain text and i-pod notes) which makes the modules created quite flexible. It is also very good at reusing 'modules' so you can export or import pre-built chunks of content.
For those making content for a more corporate environment the styles applied to the pages might not be such a good 'fit' but as it's CSS driven you can develop your own. If you create any particularly nice styles then please post them on the eXe forum.
There is a specific 'ready run' version down loadable from http://www.exelearning.org
Has anyone tried running XAMPP with Moodle or any other LMS off of a stick?