Program: Desura
License: Open Source/GPL
Description: A game client that is focused towards indie games and mods
Website: http://www.desura.com/
Other: original version uses admin privs to update first time, then no longer needs them
New: MKVToolNix (May 01, 2024), Platform 29.5 (Apr 24, 2024)
1,100+ portable packages, 1.1 billion downloads
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The open source build is actually called Desurium. While there are instructions on how to build the Windows client, they currently do not host their own Windows build. I'm waiting to see if they offer their own build in the future (or if anyone else wants to go for it, go for it).
https://github.com/lodle/Desurium