This was partly covered already, I just had a little bit to add. First of all I wanted to says thank you to John and all who help. This is a wonderful website with a ton of stuff... Couldn't be happier.
Everytime I run Portable Gimp, I get a .gtk-bookmarks and a .fonts.cache file added to "My Documents" And after I have a opened up a picture. I get a .thumbnails folder. Just wondering if anyone else was experiancing this as well and wondering about a possible fix