Why can't I save the Message filters info?

I change a computer so I copy the whole thunderbird Portable to my new computer.

The Thunderbird Portable works fine on my computer except that it can't record my new Message filters info. When I modify my Message Filters, the thunderbird works immediately and correctly.

But after I shut down and restart the thunderbird portable, the new message filters are gone. I don't know why.

I can't modify the filters config file manually:
ThunderbirdPortable\Data\profile\ImapMail\11.11.11.11\msgFilterRules.dat

But just can't save the change to this config file in thunderbird.

What's wrong with my thunderbird portable?