Restart of Thunderbird internal command is ok?

Hi,
i know from the installed TB installation the restart option i.e. after installing a new addon. In my imagine the portableapp version could be influence the behaviour (settings will not be stored or registry entries were not removed, something like that).

So my question: Is it ok to restart TP-portable with the TB internal given command? Or should i close TB-portable compeletely and start the program again afterwards.

Let me ask a question with little overlap to Firefox-PP :). Same question about that program.

Thx in advance