This is a two-part error, and I'm starting with the last part.
I got this error popup window upon starting TB Portable:
Mozilla Thunderbird, Portable Edition | PortableApps.com
Integrity Failure Warning: Mozilla Thunderbird, Portable Edition was installed or upgraded without using its installer and some critical files may have been modified. This could cause data loss, personal data left behind on a shared PC, functionality issues, and/or may be a violation of the application's license. Please visit PortableApps.com to obtain the official release of this application to install or upgrade. If you wish to use this application in its current unsupported state, please click OK to continue.
As I didn't want to run it, and there was no other button option than "OK", I closed that window (klicked X top right).
TB started anyway!
And I got another error popup window
Couldn't load XPCOM.
Please let me choose here to not start it.
Here comes part two:
I know why the XPCOM error happened, and it was because I had checked the Help/About and it said Update availabele.
"Great!" Klick. Oh (facepalm) I have PortableApps …
BUT it worked, no problem, after that.
No problem, and no Integrity Failure Warning!
Not even when the PA platform found the new PA update and installed it – and, again said nothing.
THAT only happened when I started the program.
Yes, ThunderbirdPortable.exe, I have a shortcut to it.
Why didn't the Integrity Failure Warning happen on first start after I had manually updated?
A reinstall with downloaded .paf installer fixed the problem. All's well.