This appears to be a common error, associated with mixing 32bit and 64bit DLLs?
Most of my PortableApps are suddenly failing with this on my Windows 10, x64 machine where Portable Apps in in fact installed on my secondary hard drive.
Some apps will run successfully, noteabley, Firefox, Chrome and one or two other native 64bit applications. I tried re-installing PortableApps itself. It runs fine, only the portable.exe apps fail. E.G. Notepad2Portable.exe fails but Notepad2.exe in the App folder will run just fine? Attempting to re-install individual applications fails because the PAF.exe executable fails with the same error. Any suggestions would be appreciated.