I've noticed with 10.0.1, I get a crash when PortableApp is running (with a usb drive) and you put the computer into sleep mode. When you come back, PortableApp errors out when you mouse over it or right click the icon to exit. You cannot quit the application and must kill it in task-manager. Windows 7 32bit and 64bit (two different machines).
Under these circumstances, PA used to just unload itself and you'd restart it.
I'll try to grab the error details next time.