Moved to a pre-release topic here:
Just found this one, I think it would classify to me as the best open source desktop note taking program out there. Apparently all of its settings are self contained, and I can verify nothing in the registry. I think if it were put in the PortableApps Format, and a launcher was created, a lot of people would benefit from it if PortableApps.com hosted it.
Here's the link.
Who agrees with me? It's got a few extra languages too.