Xenon Portable Pre-Release 6 [File Manager] (Please Test)
Xenon is a file manager with locally stored file extensions. This is a complete rewrite of Xenon in AutoIt (the second rewrite actually). It should work on most computers now. The assoc.ini file has the icons and file associations. There are no default portable applications set to open files but there are lines commented out that enable most files to be launched.
Edit: Pre-Release 3 adds many features including copy+paste, a context menu, and plugin system.
Edit: Pre-Release 4 includes a zip extraction program based on 7-Zip for n00bs called 6-Zip and plugin examples and installers.
and I use others apps on my USB-stick - skype, PSI, Total Commander, Private Data and many more. Sometimes i had problems with run them from it - it was many .exe files in directory, application must have som params or environment variables set berore it is run.